A replication-competent, neutralization-sensitive variant of simian immunodeficiency virus lacking 100 amino acids of envelope.

@article{Johnson2002ARN,
  title={A replication-competent, neutralization-sensitive variant of simian immunodeficiency virus lacking 100 amino acids of envelope.},
  author={Welkin E Johnson and Jennifer I Morgan and Julie N. Reitter and Bridget A. Puffer and Susan Czajak and Robert W. Doms and Ronald C Desrosiers},
  journal={Journal of virology},
  year={2002},
  volume={76 5},
  pages={2075-86}
}
Coding sequences for the first two variable loops of the gp120 envelope glycoprotein were removed from simian immunodeficiency virus (SIV) strain 239 (SIVmac239). This deletion encompassed 100 amino acids. The resulting virus replicated poorly after transfection into immortalized T-cell lines, with peak replication occurring only after 25 to 30 days. Limited passaging of SIVmac239DeltaV1V2 in cultures gave rise to a variant which had significantly improved replication kinetics but which… CONTINUE READING
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