A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorder.

@article{Caspi2008ARM,
  title={A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorder.},
  author={Avshalom Caspi and Kate Langley and Barry Milne and Terrie E Moffitt and Michael O'Donovan and Michael J. Owen and Monica Polo Tomas and Richie G. Poulton and Michael Rutter and Alan Taylor and Benjamin Williams and Anita Thapar},
  journal={Archives of general psychiatry},
  year={2008},
  volume={65 2},
  pages={
          203-10
        }
}
CONTEXT Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous neurodevelopmental disorder that in some cases is accompanied by antisocial behavior. OBJECTIVE To test if variations in the catechol O-methyltransferase gene (COMT) would prove useful in identifying the subset of children with ADHD who exhibit antisocial behavior. DESIGN Three independent samples composed of 1 clinical sample of ADHD cases and 2 birth cohort studies. PARTICIPANTS Participants in the clinical… CONTINUE READING
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