A repeated dose comparison of three benzodiazepine derivatives (nitrazepam, flurazepam and flunitrazepam) on subjective appraisals of sleep and measures of psychomotor performance the morning following night‐time medication

@article{Hindmarch1977ARD,
  title={A repeated dose comparison of three benzodiazepine derivatives (nitrazepam, flurazepam and flunitrazepam) on subjective appraisals of sleep and measures of psychomotor performance the morning following night‐time medication},
  author={Ian Hindmarch},
  journal={Acta Psychiatrica Scandinavica},
  year={1977},
  volume={56}
}
  • I. Hindmarch
  • Published 1 November 1977
  • Psychology, Medicine
  • Acta Psychiatrica Scandinavica
Repeated doses of 5 mg nitrazepam, 15 mg flurazepam, and 1 mg flunitrazepam improved subjective assessments of the ease of getting to sleep and the perceived quality of induced sleep in a population of 30 healthy volunteers. The subjective reports of improved sleep inducement were related to a perceived difficulty in awakening from sleep the morning following medication. This subjectively reported “hangover” is also shown in the impairment of mental arithmetic abilities as measured on the… 
The effects of clobazam and lorazepam on aspects of psychomotor performance and car handling ability.
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The results taken as a whole show important differences between the 1,4 benzodiazepine, lorazepam, and the 2,5 benzodiazine, clobazam, in their effects on the integrity of psychomotor performance related to car driving ability.
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  • I. Hindmarch
  • Psychology
    British journal of clinical pharmacology
  • 1979
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A Double-blind, Placebo- and Flurazepam-controlled Investigation of the Residual Psychomotor and Cognitive Effects of Modified Release Zolpidem in Young Healthy Volunteers
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Although long-acting drugs generally showed more performance decrement, half-life data were not consistent, and, in comparing active drug to placebo, it is clear that all hypnotics, at some doses, produce decrements in performance the next day.
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