A remote and highly conserved enhancer supports amygdala specific expression of the gene encoding the anxiogenic neuropeptide substance-P

@article{Davidson2006ARA,
  title={A remote and highly conserved enhancer supports amygdala specific expression of the gene encoding the anxiogenic neuropeptide substance-P},
  author={Scott Davidson and Kerry Ann Miller and Anthony Dowell and Aideen Gildea and Alasdair F. Mackenzie},
  journal={Molecular Psychiatry},
  year={2006},
  volume={11},
  pages={410-421}
}
The neuropeptide substance P (SP), encoded by the preprotachykinin-A (PPTA) gene, is expressed in the central and medial amygdaloid nucleus, where it plays a critical role in modulating fear and anxiety related behaviour. Determining the regulatory systems that support PPTA expression in the amygdala may provide important insights into the causes of depression and anxiety related disorders and will provide avenues for the development of novel therapies. In order to identify the tissue specific… CONTINUE READING
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