A remarkable increase in the pHi sensitivity of voltage-dependent calcium channels occurs in human sperm incubated in capacitating conditions.

@article{NeriVidaurri2006ARI,
  title={A remarkable increase in the pHi sensitivity of voltage-dependent calcium channels occurs in human sperm incubated in capacitating conditions.},
  author={Paloma del Carmen Neri-Vidaurri and V{\'i}ctor Torres-Flores and Marco T. Gonzalez-Martinez},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={343 1},
  pages={105-9}
}
Human sperm are endowed with voltage-dependent calcium channels (VDCC) that produce increases in [Ca2+]i in response to depolarization with KCl. These channels are stimulated during "capacitation", a complex biochemical process, accompanied by a slight pHi alkalization, that sperm must accomplish to acquire the ability to fertilize the egg. The stimulation… CONTINUE READING