A relatively stable antifungal peptide from buckwheat seeds with antiproliferative activity toward cancer cells.

@article{Leung2007ARS,
  title={A relatively stable antifungal peptide from buckwheat seeds with antiproliferative activity toward cancer cells.},
  author={Edwin H W Leung and T. B. Ng},
  journal={Journal of peptide science : an official publication of the European Peptide Society},
  year={2007},
  volume={13 11},
  pages={762-7}
}
An antifungal peptide with a molecular mass of approximately 4 kDa was isolated from buckwheat seeds by using ion-exchange chromatography on SP-Sepharose and Q-Sepharose, and gel filtration on Superdex peptide. The peptide was adsorbed on SP-Sepharose in 10 mM NH(4)OAc buffer (pH 4.5) and on Q-Sepharose in 10 mM NH(4)HCO(3) buffer (pH 9.4), and appeared to be highly purified after these two steps. It inhibited mycelial growth in Fusarium oxysporum and Mycosphaerella arachidicola with an IC(50… CONTINUE READING

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