A relative ordering-based predictor for tamoxifen-treated estrogen receptor-positive breast cancer patients: multi-laboratory cohort validation

@article{Zhou2013ARO,
  title={A relative ordering-based predictor for tamoxifen-treated estrogen receptor-positive breast cancer patients: multi-laboratory cohort validation},
  author={Xianxiao Zhou and Bailiang Li and Yuannv Zhang and Yunyan Gu and Beibei Chen and Tongwei Shi and Lu Ao and Pengfei Li and Shan Li and Chunyang Liu and Zheng Guo},
  journal={Breast Cancer Research and Treatment},
  year={2013},
  volume={142},
  pages={505-514}
}
Current predictors for estrogen receptor-positive (ER-positive) breast cancer patients receiving tamoxifen are often invalid in inter-laboratory validation. We aim to develop a robust predictor based on the relative ordering of expression measurement (ROE) in gene pairs. Using a large integrated dataset of 420 normal controls and 1,129 ER-positive breast tumor samples, we identified the gene pairs with stable ROEs in normal control and significantly reversed ROEs in ER-positive tumor. Using… CONTINUE READING
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