A relationship between replicon size and supercoiled loop domains in the eukaryotic genome

@article{BuongiornoNardelli1982ARB,
  title={A relationship between replicon size and supercoiled loop domains in the eukaryotic genome},
  author={Mario Buongiorno-Nardelli and Gioacchino Micheli and Maria Teresa Carr{\`i} and Monique Marilley},
  journal={Nature},
  year={1982},
  volume={298},
  pages={100-102}
}
In interphase nuclei and metaphase chromosomes, eukaryotic chromosomal DNA is arranged in negatively supercoiled loops whose length averages several tens of kilobases (kb). Supercoiling indicates that the loops are tenaciously bound at both ends through the periodic attachment of DNA to a non-histone protein structural support, termed the nuclear matrix, skeleton or cage in interphase nuclei and the scaffold in metaphase chromosomes1–16. The looped organization has been envisaged to be… CONTINUE READING

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