A reinvestigation of the acid-promoted heterocyclization of 2-(2-oxo-2-arylethyl)malononitriles in the presence of amines

@article{Martins2009ARO,
  title={A reinvestigation of the acid-promoted heterocyclization of 2-(2-oxo-2-arylethyl)malononitriles in the presence of amines},
  author={Carla Martins and A. Eleut{\'e}rio and M. Carreiras and Abdelouahid Samadi and E. Soriano and R. Le{\'o}n and J. Marco-Contelles},
  journal={Molecular Diversity},
  year={2009},
  volume={13},
  pages={459-468}
}
The reinvestigation of the acid-promoted cyclization of 2-(2-oxo-2-arylethyl)malononitriles, in the presence of benzylamine or aniline, in ethanol or acetonitrile, has confirmed that this is a long-time reaction process for a low-yielding synthesis of 2-amino-5-arylfuran-3-carbonitriles (2), or 2-amino-5-aryl-1-phenyl-1H-pyrrole-3-carbonitriles (4), depending on the base used. However, the microwave-assisted synthesis of 2-amino-5-(4′-methoxyphenyl)furan-3(4)-(di)carbonitriles (2c and 3c… Expand
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