A reinvestigation of somatic hypermethylation at the PTEN CpG island in cancer cell lines

@inproceedings{Hesson2012ARO,
  title={A reinvestigation of somatic hypermethylation at the PTEN CpG island in cancer cell lines},
  author={Luke B. Hesson and Deborah Packham and Emily A Pontzer and Pauline Funchain and Charis Eng and Robyn Lynne Ward},
  booktitle={Biological Procedures Online},
  year={2012}
}
PTEN is an important tumour suppressor gene that is mutated in Cowden syndrome as well as various sporadic cancers. CpG island hypermethylation is another route to tumour suppressor gene inactivation, however, the literature regarding PTEN hypermethylation in cancer is controversial. Furthermore, investigation of the methylation status of the PTEN CpG island is challenging due to sequence homology with the PTEN pseudogene, PTENP1. PTEN shares a CpG island promoter with another gene known as… CONTINUE READING
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