A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation.

@article{Gale2006ARR,
  title={A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation.},
  author={Sarah E. Gale and Andrey N. Frolov and Xianlin Han and Perry E Bickel and Li Cao and Anne M Bowcock and Jean E Schaffer and Daniel S Ory},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 16},
  pages={
          11082-9
        }
}
Mutations in the 1-acylglycerol-3-phosphate-O-acyltransferase 2 (AGPAT2) gene have been identified in individuals affected with congenital generalized lipodystrophy (CGL). AGPAT2 catalyzes acylation of lysophosphatidic acid to phosphatidic acid, a precursor for both triacylglycerol (TAG) and phospholipid synthesis. Recent studies suggest that reduced AGPAT2 enzymatic activity may underlie the CGL clinical phenotype. To gain insight into how altered AGPAT2 activity causes lipodystrophy, we… CONTINUE READING
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