A regulatory effect of IL-21 on T follicular helper-like cell and B cell in rheumatoid arthritis

@inproceedings{Liu2012ARE,
  title={A regulatory effect of IL-21 on T follicular helper-like cell and B cell in rheumatoid arthritis},
  author={Rui Liu and Qian Wu and Dinglei Su and Nan Che and Hai-Feng Chen and Linyu Geng and Jinyun Chen and Wanjun Chen and Xia Chong Li and Lingyun Sun},
  booktitle={Arthritis research & therapy},
  year={2012}
}
INTRODUCTION Interleukin (IL)-21 is a member of type I cytokine family. Recent studies indicate that IL-21 can promote T follicular helper (Tfh) cell differentiation and survival, a specialized T cell subset which provides help for B cell. It can also regulate the activation, proliferation and differentiation of human B cell and immunoglobulin (Ig) production as well as isotype switching of plasma cell. Rheumatoid arthritis (RA) is characterized by auto-antibodies overproduction such as… CONTINUE READING