A regulatory cytoplasmic poly(A) polymerase in Caenorhabditis elegans

  title={A regulatory cytoplasmic poly(A) polymerase in Caenorhabditis elegans},
  author={Liaoteng Wang and Christian R Eckmann and Lisa C. Kadyk and Marvin Wickens and Judith Kimble},
Messenger RNA regulation is a critical mode of controlling gene expression. Regulation of mRNA stability and translation is linked to controls of poly(A) tail length. Poly(A) lengthening can stabilize and translationally activate mRNAs, whereas poly(A) removal can trigger degradation and translational repression. Germline granules (for example, polar granules in flies, P granules in worms) are ribonucleoprotein particles implicated in translational control. Here we report that the… CONTINUE READING
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Identification and functional characterization of neo-poly(A) polymerase, an RNA processing enzyme overexpressed in human tumors

  • Topalian, L S.
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