A regulatory circuit mediating convergence between Nurr1 transcriptional regulation and Wnt signaling.

@article{Kitagawa2007ARC,
  title={A regulatory circuit mediating convergence between Nurr1 transcriptional regulation and Wnt signaling.},
  author={Hirochika Kitagawa and William J. Ray and Helmut Glantschnig and Pascale V. Nantermet and Yuanjiang Yu and Chih-Tai Leu and Shun-ichi Harada and Shigeaki Kato and Leonard P. Freedman},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 21},
  pages={7486-96}
}
The orphan nuclear receptor Nurr1 is essential for the development and maintenance of midbrain dopaminergic neurons, the cells that degenerate during Parkinson's disease, by promoting the transcription of genes involved in dopaminergic neurotransmission. Since Nurr1 lacks a classical ligand-binding pocket, it is not clear which factors regulate its activity and how these factors are affected during disease pathogenesis. Since Wnt signaling via beta-catenin promotes the differentiation of Nurr1… CONTINUE READING

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