A regulator of G protein signaling interaction surface linked to effector specificity.

@article{Sowa2000ARO,
  title={A regulator of G protein signaling interaction surface linked to effector specificity.},
  author={Mathew E. Sowa and Wei He and Theodore G Wensel and Olivier Lichtarge},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 4},
  pages={1483-8}
}
Proteins of the regulator of G protein signaling (RGS) family accelerate GTP hydrolysis by the alpha subunits (G(alpha)) of G proteins, leading to rapid recovery of signaling cascades. Many different RGS proteins can accelerate GTP hydrolysis by an individual G(alpha), and GTP hydrolysis rates of different G(alpha)s can be enhanced by the same RGS protein. Consequently, the mechanisms for specificity in RGS regulation and the residues involved remain unclear. Using the evolutionary trace (ET… CONTINUE READING