A region to the N-terminal side of the CTCF zinc finger domain is essential for activating transcription from the amyloid precursor protein promoter.

@article{Vostrov2002ART,
  title={A region to the N-terminal side of the CTCF zinc finger domain is essential for activating transcription from the amyloid precursor protein promoter.},
  author={Alexander A. Vostrov and Michael J Taheny and Wolfgang W. Quitschke},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 2},
  pages={1619-27}
}
Transcription from the amyloid precursor protein (APP) promoter is largely dependent on a nuclear factor binding site designated as APBbeta. The protein that binds to this site is the multifunctional transcription factor CTCF, which consists of 727 amino acids and contains a domain of 11 zinc finger motifs that is flanked by 267 amino acids on the N-terminal side and 150 amino acids on the C-terminal side. Depleting HeLa cell nuclear extract of endogenous CTCF specifically reduced… CONTINUE READING

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