A region of the ryanodine receptor critical for excitation-contraction coupling in skeletal muscle.

@article{Yamazawa1997ARO,
  title={A region of the ryanodine receptor critical for excitation-contraction coupling in skeletal muscle.},
  author={Toshiko Yamazawa and Hiroshi Takeshima and M. Shimuta and Masamitsu Iino},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 13},
  pages={8161-4}
}
Ca2+ release mediated by the ryanodine receptor (RyR) regulates many important cell functions including excitation-contraction (E-C) coupling in skeletal muscle, by which membrane depolarization controls the opening of RyR via the dihydropyridine receptor. Among the three RyR subtypes, RyR-1 mediates skeletal muscle E-C coupling, whereas RyR-2 and RyR-3 cannot substitute for RyR-1. We carried out expression experiments using cultured mutant skeletal myocytes not having intrinsic intracellular… CONTINUE READING
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