• Biology, Medicine
  • Published in Genetics 1999

A region of the Sir1 protein dedicated to recognition of a silencer and required for interaction with the Orc1 protein in saccharomyces cerevisiae.

@article{Gardner1999ARO,
  title={A region of the Sir1 protein dedicated to recognition of a silencer and required for interaction with the Orc1 protein in saccharomyces cerevisiae.},
  author={Kelly A Gardner and Jasper Rine and Catherine A Fox},
  journal={Genetics},
  year={1999},
  volume={151 1},
  pages={
          31-44
        }
}
Silencing of the cryptic mating-type loci HMR and HML requires the recognition of DNA sequence elements called silencers by the Sir1p, one of four proteins dedicated to the assembly of silenced chromatin in Saccharomyces cerevisiae. The Sir1p is thought to recognize silencers indirectly through interactions with proteins that bind the silencer DNA directly, such as the origin recognition complex (ORC). Eight recessive alleles of SIR1 were discovered that encode mutant Sir1 proteins specifically… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 25 REFERENCES

The the other Sir proteins. Thus, in the absence of a region

A. E. Ehrenhofer-Murray, M. D. Rivier, J. Rine
  • 1996
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Silencing and heritable domains of gene expression.

  • Annual review of cell and developmental biology
  • 1995
VIEW 5 EXCERPTS

JRY3009 MATa ade2-1

Thomas, Rothstein
  • HMR-SSa
  • 1989
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

pMA424 2mm HIS3 vector containing GAL4-SIR1 under the control

Sikorski, Hieter
  • 1989
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL