A region of antisense RNA from human p120 cDNA with high homology to mouse p120 cDNA inhibits NIH 3T3 proliferation.

@article{Valdez1992ARO,
  title={A region of antisense RNA from human p120 cDNA with high homology to mouse p120 cDNA inhibits NIH 3T3 proliferation.},
  author={Benigno C. Valdez and Laszlo Perlaky and Yasuo Saijo and Dale Henning and Chaoyong Zhu and Rose K. Busch and Wei Zhang and Harris Busch},
  journal={Cancer research},
  year={1992},
  volume={52 20},
  pages={5681-6}
}
The human nucleolar p120 protein is a proliferation-associated antigen which is expressed in G1 and peaks during the early S phase of the cell cycle. Overexpression of the human p120 protein caused the transformation of NIH 3T3 cells and expression of an antisense p120 construct inhibited the growth of NIH 3T3 cells (Perlaky et al., Cancer Res., 52:428-436, 1992). The middle region of the antisense p120 RNA was found to be almost as inhibitory as the full length antisense construct but the 5… CONTINUE READING