A refined two-hybrid system reveals that SCF(Cdc4)-dependent degradation of Swi5 contributes to the regulatory mechanism of S-phase entry.

@article{Kishi2008ART,
  title={A refined two-hybrid system reveals that SCF(Cdc4)-dependent degradation of Swi5 contributes to the regulatory mechanism of S-phase entry.},
  author={Tsutomu Kishi and Akemi Ikeda and Noriko Koyama and Junji Fukada and Rina Nagao},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 38},
  pages={14497-502}
}
Ubiquitin-dependent degradation is implicated in various cellular regulatory mechanisms. The SCF(Cdc4) (Skp1, Cullin/Cdc53, and the F-box protein Cdc4) complex is an ubiquitin ligase complex that acts as a regulator of cell cycle, signal transduction, and transcription. These regulatory mechanisms are not well defined because of the difficulty in identifying the interaction between ubiquitin ligases and their substrates. To identify substrates of the yeast SCF(Cdc4) ubiquitin ligase complex, we… CONTINUE READING

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