A refined method for the meta-analysis of controlled clinical trials with binary outcome.

@article{Hartung2001ARM,
  title={A refined method for the meta-analysis of controlled clinical trials with binary outcome.},
  author={Joachim Hartung and Guido Knapp},
  journal={Statistics in medicine},
  year={2001},
  volume={20 24},
  pages={3875-89}
}
For the meta-analysis of controlled clinical trials with binary outcome a test statistic for testing an overall treatment effect is proposed, which is based on a refined estimator for the variance of the treatment effect estimator usually used in the random-effects model of meta-analysis. In simulation studies it is shown that the proposed test keeps the prescribed significance level much better than the commonly used tests in the fixed-effects and random-effects model, respectively. Moreover… CONTINUE READING

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