A reexamination of active and passive tumor targeting by using rod-shaped gold nanocrystals and covalently conjugated peptide ligands.

@article{Huang2010ARO,
  title={A reexamination of active and passive tumor targeting by using rod-shaped gold nanocrystals and covalently conjugated peptide ligands.},
  author={Xiaohua Huang and Xianghong Peng and Yiqing Wang and Yuxiang Wang and Dong M Shin and Mostafa A El-Sayed and Shuming Nie},
  journal={ACS nano},
  year={2010},
  volume={4 10},
  pages={5887-96}
}
The targeted delivery of nanoparticles to solid tumors is one of the most important and challenging problems in cancer nanomedicine, but the detailed delivery mechanisms and design principles are still not well understood. Here we report quantitative tumor uptake studies for a class of elongated gold nanocrystals (called nanorods) that are covalently conjugated to tumor-targeting peptides. A major advantage in using gold as a "tracer" is that the accumulated gold in tumors and other organs can… CONTINUE READING

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