A reevaluation of integrins as regulators of angiogenesis


Pharmacological agents directed against the integrins alpha(v)beta(3) and alpha(v)beta(5) have been reported to inhibit angiogenesis. However, genetic ablations of the genes encoding these integrins fail to block angiogenesis and in some cases even enhance it. This apparent paradox suggests the hypotheses that these integrins are negative regulators of… (More)
DOI: 10.1038/nm0902-918


  • Presentations referencing similar topics