A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes

@article{Cree2008ARO,
  title={A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes},
  author={L. M. Cree and D. Samuels and S. C. D. S. Lopes and H. Rajasimha and Passorn Wonnapinij and J. Mann and Hans-Henrik M. Dahl and P. Chinnery},
  journal={Nature Genetics},
  year={2008},
  volume={40},
  pages={249-254}
}
  • L. M. Cree, D. Samuels, +5 authors P. Chinnery
  • Published 2008
  • Biology, Medicine
  • Nature Genetics
  • Mammalian mitochondrial DNA (mtDNA) is inherited principally down the maternal line, but the mechanisms involved are not fully understood. Females harboring a mixture of mutant and wild-type mtDNA (heteroplasmy) transmit a varying proportion of mutant mtDNA to their offspring. In humans with mtDNA disorders, the proportion of mutated mtDNA inherited from the mother correlates with disease severity. Rapid changes in allele frequency can occur in a single generation. This could be due to a marked… CONTINUE READING
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