A reduction in the in situ rates of oxygen and glucose consumption of cells in EMT6/Ro spheroids during growth.

@article{Freyer1985ARI,
  title={A reduction in the in situ rates of oxygen and glucose consumption of cells in EMT6/Ro spheroids during growth.},
  author={James P. Freyer and Robert Murray Sutherland},
  journal={Journal of cellular physiology},
  year={1985},
  volume={124 3},
  pages={
          516-24
        }
}
The rates of consumption of oxygen and glucose by EMT6/Ro cells in multicellular spheroids were measured at various times during normal growth. In situ spheroid cellular consumption rates were similar to those of exponentially growing single cells up to a spheroid diameter of 150 micron. Further growth resulted in decreases in the rates of both oxygen and glucose consumption which were correlated with the increase in spheroid diameter and cell number. At a diameter of 1300 micron, both rates of… CONTINUE READING
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