A redox‐based mechanism for nitric oxide‐induced inhibition of DNA synthesis in human vascular smooth muscle cells

  title={A redox‐based mechanism for nitric oxide‐induced inhibition of DNA synthesis in human vascular smooth muscle cells},
  author={R. Bundy and N. Marczin and A. Chester and M. Yacoub},
  journal={British Journal of Pharmacology},
The current study explored potential redox mechanisms of nitric oxide (NO)‐induced inhibition of DNA synthesis in cultured human and rat aortic smooth muscle cells. Exposure to S‐nitrosothiols, DETA‐NONOate and NO itself inhibited ongoing DNA synthesis and S phase progression in a concentration‐dependent manner, as measured by thymidine incorporation and flow cytometry. Inhibition by NO donors occurred by release of NO, as detected by chemiluminescence and judged by the effects of NO scavengers… Expand
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