A recurrent RNA-binding domain is appended to eukaryotic aminoacyl-tRNA synthetases.

@article{Cahuzac2000ARR,
  title={A recurrent RNA-binding domain is appended to eukaryotic aminoacyl-tRNA synthetases.},
  author={B Cahuzac and E Berthonneau and Nicolas Birlirakis and Eric Guittet and Marc Mirande},
  journal={The EMBO journal},
  year={2000},
  volume={19 3},
  pages={445-52}
}
Aminoacyl-tRNA synthetases of higher eukaryotes possess polypeptide extensions in contrast to their prokaryotic counterparts. These extra domains of poorly understood function are believed to be involved in protein-protein or protein-RNA interactions. Here we showed by gel retardation and filter binding experiments that the repeated units that build the linker region of the bifunctional glutamyl-prolyl-tRNA synthetase had a general RNA-binding capacity. The solution structure of one of these… CONTINUE READING

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