A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma.

@article{Salaverria2014AR1,
  title={A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma.},
  author={Itziar Salaverria and Idoia Mart{\'i}n-Guerrero and Rabea Wagener and Markus Kreuz and Christian W. Kohler and Julia Richter and Barbara Pieńkowska-Grela and P. Patterson Adam and Birgit Burkhardt and Alexander Claviez and Christine Damm-Welk and Hans Gunther Drexler and Michael Hummel and Elaine S. Jaffe and Ralf K{\"u}ppers and Christine Lefebvre and Jasmin Lisfeld and Markus Dipl.-Ing. L{\"o}ffler and Roderick A. F. Macleod and Inga Nagel and Ilske Oschlies and Maciej Rosolowski and Robert B Russell and Grzegorz Rymkiewicz and Detlev Schindler and Matthias Schlesner and Ren{\'e} Scholtysik and Carsten Schwaenen and Rainer Spang and M. Szczepanowski and Lorenz H. Truemper and Inga Vater and Swen Wessendorf and Wolfram Klapper and Reiner Siebert},
  journal={Blood},
  year={2014},
  volume={123 8},
  pages={
          1187-98
        }
}
The genetic hallmark of Burkitt lymphoma (BL) is the t(8;14)(q24;q32) and its variants leading to activation of the MYC oncogene. It is a matter of debate whether true BL without MYC translocation exists. Here, we identified 59 lymphomas concordantly called BL by 2 gene expression classifiers among 753 B-cell lymphomas. Only 2 (3%) of these 59 molecular BL lacked a MYC translocation, which both shared a peculiar pattern of chromosome 11q aberration characterized by interstitial gains including… CONTINUE READING

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