A reconfigured pattern of MLL occupancy within mitotic chromatin promotes rapid transcriptional reactivation following mitotic exit.

@article{Blobel2009ARP,
  title={A reconfigured pattern of MLL occupancy within mitotic chromatin promotes rapid transcriptional reactivation following mitotic exit.},
  author={Gerd A Blobel and Stephan Kadauke and Eric Shing-Suan Wang and Alan C. W. Lau and Johannes Zuber and Margaret M. Chou and Christopher R Vakoc},
  journal={Molecular cell},
  year={2009},
  volume={36 6},
  pages={970-83}
}
Mixed lineage leukemia (MLL) and its metazoan Trithorax orthologs have been linked with the epigenetic maintenance of transcriptional activity. To identify mechanisms by which MLL perpetuates active transcription in dividing cells, we investigated its role during M phase of the cell cycle. Unlike other chromatin-modifying enzymes examined, we found that MLL associates with gene promoters packaged within condensed mitotic chromosomes. Genome-wide location analysis identified a globally… CONTINUE READING
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