A recombination hot spot in the Rh genes revealed by analysis of unrelated donors with the rare D-- phenotype.

@article{Kemp1996ARH,
  title={A recombination hot spot in the Rh genes revealed by analysis of unrelated donors with the rare D-- phenotype.},
  author={Toby John Kemp and Mark Poulter and Ben Carritt},
  journal={American journal of human genetics},
  year={1996},
  volume={59 5},
  pages={
          1066-73
        }
}
We have studied the arrangement of Rh (rhesus) genes in donors who are completely null for the products of one of them, RHCE. We show that five of six homozygous individuals with the so-called Rh D-- phenotype, who express no red-cell antigens of the C/c and E/e series, have rearranged RHCE genes in which internal sequences have been replaced by the corresponding sequences from RHD. Moreover, although there is heterogeneity at the 3' end, the 5' boundary of this chimerism is within the same… CONTINUE READING

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