A recombination hot spot in HIV-1 contains guanosine runs that can form a G-quartet structure and promote strand transfer in vitro.

@article{Shen2009ARH,
  title={A recombination hot spot in HIV-1 contains guanosine runs that can form a G-quartet structure and promote strand transfer in vitro.},
  author={Wen Hong Shen and Lu Gao and Mini P. Balakrishnan and Robert A Bambara},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 49},
  pages={33883-93}
}
The co-packaged RNA genomes of human immunodeficiency virus-1 recombine at a high rate. Recombination can mix mutations to generate viruses that escape immune response. A cell-culture-based system was designed previously to map recombination events in a 459-bp region spanning the primer binding site through a portion of the gag protein coding region. Strikingly, a strong preferential site for recombination in vivo was identified within a 112-nucleotide-long region near the beginning of gag… CONTINUE READING
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