A recombinant vesicular stomatitis virus bearing a lethal mutation in the glycoprotein gene uncovers a second site suppressor that restores fusion.

@article{Stanifer2011ARV,
  title={A recombinant vesicular stomatitis virus bearing a lethal mutation in the glycoprotein gene uncovers a second site suppressor that restores fusion.},
  author={Megan L Stanifer and David K. Cureton and Sean P. J. Whelan},
  journal={Journal of virology},
  year={2011},
  volume={85 16},
  pages={8105-15}
}
Vesicular stomatitis virus (VSV), a prototype of the Rhabdoviridae family, contains a single surface glycoprotein (G) that is responsible for attachment to cells and mediates membrane fusion. Working with the Indiana serotype of VSV, we employed a reverse genetic approach to produce fully authentic recombinant viral particles bearing lethal mutations in the… CONTINUE READING