A recombinant vaccinia virus containing the papilloma E2 protein promotes tumor regression by stimulating macrophage antibody-dependent cytotoxicity

@article{Rosales2000ARV,
  title={A recombinant vaccinia virus containing the papilloma E2 protein promotes tumor regression by stimulating macrophage antibody-dependent cytotoxicity},
  author={Carlos Rosales and Viviana Valadez Graham and Gerardo Arrell{\'i}n Rosas and Horacio Merchant and Ricardo Rosales},
  journal={Cancer Immunology, Immunotherapy},
  year={2000},
  volume={49},
  pages={347-360}
}
Human papillomavirus infection is associated with cervical cancer. The E6 and E7 papillomavirus proteins are normally required for the maintenance of the malignant phenotype. Expression of these proteins in infected cells is negatively regulated by the binding of the papilloma E2 protein to the long terminal control region of the papilloma virus genome. The E2 protein can also promote cell arrest and apoptosis in HeLa cells. Therefore, it is clear that this protein has the potential of… CONTINUE READING

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