A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner

Abstract

Increasing the in vivo residence times of protein therapeutics could decrease their dosing frequencies. We show that genetic fusion of an unstructured recombinant polypeptide of 864 amino acids, called XTEN, to a peptide or protein provides an apparently generic approach to extend plasma half-life. Allometric scaling suggests that a fusion of XTEN to the… (More)
DOI: 10.1038/nbt.1588

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Cite this paper

@article{Schellenberger2009ARP, title={A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner}, author={Volker Schellenberger and Chia-Wei Wang and Nathan C. Geething and Benjamin J. Spink and Andrew Campbell and Wayne To and M Scholle and Yong Yin and Yi Yao and Oren Bogin and Jeffrey L. Cleland and Joshua Silverman and Willem P. C. Stemmer}, journal={Nature Biotechnology}, year={2009}, volume={27}, pages={1186-1190} }