A recombinant platform for flavivirus vaccines and diagnostics using chimeras of a new insect-specific virus

@article{HobsonPeters2019ARP,
  title={A recombinant platform for flavivirus vaccines and diagnostics using chimeras of a new insect-specific virus},
  author={Jody Hobson-Peters and Jessica J. Harrison and Daniel Watterson and Jessamine E Hazlewood and Laura J. Vet and Natalee D. Newton and David Warrilow and Agathe M G Colmant and Carmel T Taylor and Bixing Huang and Thisun B. H. Piyasena and Weng Kong Chow and Yin Xiang Setoh and Bing Tang and Eri Nakayama and Kexin Yan and Alberto A. Amarilla and Sarah Wheatley and Peter R. Moore and Mitchell Finger and Nina Kurucz and Naphak Modhiran and Paul R. Young and Alexander A. Khromykh and Helle Bielefeldt-Ohmann and Andreas Suhrbier and Roy A. Hall},
  journal={Science Translational Medicine},
  year={2019},
  volume={11}
}
Insect-specific Binjari virus facilitates the production of chimeric virus particles of flavivirus pathogens for diagnostics and vaccines. Fighting flavi with flavi Insect-transmitted flaviviruses can cause hemorrhagic fever in humans and contribute to morbidity and mortality worldwide. Hobson-Peters et al. isolated a new flavivirus from mosquitoes in Australia that can only infect insect cells. Binjari virus permits swapping of structural proteins from other flaviviruses such as dengue or Zika… Expand
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