A recombinant measles virus unable to antagonize STAT1 function cannot control inflammation and is attenuated in rhesus monkeys.

Abstract

Measles remains a leading cause of death worldwide among children because it suppresses immune function. The measles virus (MV) P gene encodes three proteins (P, V, and C) that interfere with innate immunity, controlling STAT1, STAT2, mda5, and perhaps other key regulators of immune function. We identified here three residues in the shared domain of the P… (More)
DOI: 10.1128/JVI.00802-10

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Cite this paper

@article{Devaux2011ARM, title={A recombinant measles virus unable to antagonize STAT1 function cannot control inflammation and is attenuated in rhesus monkeys.}, author={Patricia Devaux and Andrew W. Hudacek and Gregory C. Hodge and Jorge Reyes-del Valle and Michael B. McChesney and Roberto B Cattaneo}, journal={Journal of virology}, year={2011}, volume={85 1}, pages={348-56} }