A recombinant live attenuated strain of Vibrio cholerae induces immunity against tetanus toxin and Bordetella pertussis tracheal colonization factor.

@article{Chen1998ARL,
  title={A recombinant live attenuated strain of Vibrio cholerae induces immunity against tetanus toxin and Bordetella pertussis tracheal colonization factor.},
  author={In{\^e}s Chen and Theresa Finn and Li Yanqing and Q Guoming and Rino Rappuoli and Mariagrazia Pizza},
  journal={Infection and immunity},
  year={1998},
  volume={66 4},
  pages={1648-53}
}
An attenuated strain of Vibrio cholerae was used as a carrier for the expression of heterologous antigens such as fragment C from tetanus toxin (TetC) and tracheal colonization factor from Bordetella pertussis (Tcf). In vitro, high levels of protein were obtained when the Escherichia coli nirB promoter was used and the bacteria were grown with low aeration. Intranasal immunization of mice with IEM101 expressing TetC elicited serum vibriocidal activity and induced antibodies against tetanus… CONTINUE READING
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