A recombinant immunotoxin containing a disulfide-stabilized Fv fragment.

  title={A recombinant immunotoxin containing a disulfide-stabilized Fv fragment.},
  author={Ulrich Brinkmann and Yoram Reiter and Sun Ho Jung and B Lee and Ira Pastan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={90 16},
B3(dsFv)-PE38KDEL is a recombinant immunotoxin composed of the Fv region of monoclonal antibody B3 connected to a truncated form of Pseudomonas exotoxin (PE38KDEL), in which the unstable Fv heterodimer (composed of heavy- and light-chain variable regions) is held together and stabilized by a disulfide bond [termed disulfide-stabilized Fv (dsFV)]. A computer modeled structure of the B3(Fv), made by mutating and energy minimizing the amino acid sequence and structure of McPC603, enabled us to… CONTINUE READING
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