A recombinant fragment of human SP-D reduces allergic responses in mice sensitized to house dust mite allergens.

@article{Strong2003ARF,
  title={A recombinant fragment of human SP-D reduces allergic responses in mice sensitized to house dust mite allergens.},
  author={Peter Strong and P. T. Townsend and R. Mackay and Kenneth B. M. Reid and Howard W Clark},
  journal={Clinical and experimental immunology},
  year={2003},
  volume={134 2},
  pages={181-7}
}
C57Bl6 mice sensitized to Dermatophagoides pteronyssinus and challenged with D. pteronyssinus allergen extract given intranasally followed by treatment with intranasal applications of a 60-kDa truncated, trimeric recombinant form of human SP-D (rfhSP-D) showed a significant reduction in serum IgE, IgG1, peripheral blood eosinophilia and airway hyperresponsiveness compared to saline or bovine serum albumin-treated controls. Intracellular cytokine staining of lung and spleen homogenates showed… CONTINUE READING