A reciprocal role of prostate cancer on stromal DNA damage

  title={A reciprocal role of prostate cancer on stromal DNA damage},
  author={Jheelam Banerjee and Rajeev Mishra and Xiaohong Li and Roger S. Jackson and Adrija Sharma and Neil A. Bhowmick},
DNA damage found in prostate cancer-associated fibroblasts (CAF) promotes tumor progression. In the absence of somatic mutations in CAF, epigenetic changes dictate how stromal coevolution is mediated in tumors. Seventy percent of prostate cancer patients lose expression of transforming growth factor-beta type II receptor (TGFBR2) in the stromal compartment (n=77, P-value=0.0001), similar to the rate of glutathione S-transferase P1 (GSTP1) silencing. Xenografting of human prostate cancer… CONTINUE READING
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