A recessive screen for genes regulating hematopoietic stem cells.

@article{Papathanasiou2010ARS,
  title={A recessive screen for genes regulating hematopoietic stem cells.},
  author={Peter Papathanasiou and Robert Tunningley and Diwakar R. Pattabiraman and Ping Ye and Thomas J Gonda and Belinda Whittle and Adam E Hamilton and Simon O. Cridland and Rohan Lourie and Andrew C. Perkins},
  journal={Blood},
  year={2010},
  volume={116 26},
  pages={5849-58}
}
Identification of genes that regulate the development, self-renewal, and differentiation of stem cells is of vital importance for understanding normal organogenesis and cancer; such knowledge also underpins regenerative medicine. Here we demonstrate that chemical mutagenesis of mice combined with advances in hematopoietic stem cell reagents and genome resources can efficiently recover recessive mutations and identify genes essential for generation and proliferation of definitive hematopoietic… CONTINUE READING
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