A recessive mutation leading to vertebral ankylosis in zebrafish is associated with amino acid alterations in the homologue of the human membrane-associated guanylate kinase DLG3

@article{Koenig1999ARM,
  title={A recessive mutation leading to vertebral ankylosis in zebrafish is associated with amino acid alterations in the homologue of the human membrane-associated guanylate kinase DLG3},
  author={Christoph Koenig and Yi Lin Yan and John H Postlethwait and Silke Wendler and Jos{\'e} A. Campos-Ortega},
  journal={Mechanisms of Development},
  year={1999},
  volume={86},
  pages={17-28}
}
We describe the characterization of the zebrafish homologue of the human gene DLG3. The zebrafish dlg3 gene encodes a membrane-associated guanylate kinase containing a single PDZ domain. This gene was cloned using a gene-trap construct inserted in the gene's first intron. The insertion co-segregates with a viable mutation called humpback (hmp), which leads to formation of ankylotic vertebrae in adult fishes. Insertion and mutation have both been mapped to chromosome 12, in a segment which is… CONTINUE READING

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