A recessive deletion in the GlcNAc-1-phosphotransferase gene results in peri-implantation embryonic lethality.

@article{Marek1999ARD,
  title={A recessive deletion in the GlcNAc-1-phosphotransferase gene results in peri-implantation embryonic lethality.},
  author={Kurt W. Marek and Inder K. Vijay and Jamey D Marth},
  journal={Glycobiology},
  year={1999},
  volume={9 11},
  pages={1263-71}
}
Formation of the dolichol oligosaccharide precursor is essential for the production of asparagine- (N-) linked oligosaccharides (N-glycans) in eukaryotic cells. The first step in precursor biosynthesis requires the enzyme UDP-GlcNAc: dolichol phosphate N-acetylglucosamine-1-phosphate transferase (GPT). Without GPT activity, subsequent steps necessary in constructing the oligosaccharide precursor cannot occur. Inhibition of this biosynthetic step using tunicamycin, a GlcNAc analog, produces a… CONTINUE READING

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