A receptor tyrosine kinase, UFO/Axl, and other genes isolated by a modified differential display PCR are overexpressed in metastatic prostatic carcinoma cell line DU145.

@article{Jacob1999ART,
  title={A receptor tyrosine kinase, UFO/Axl, and other genes isolated by a modified differential display PCR are overexpressed in metastatic prostatic carcinoma cell line DU145.},
  author={A. N. K. Jacob and J Kalapurakal and William Robert Davidson and Geeta Kandpal and N Dunson and Y Prashar and Raj P Kandpal},
  journal={Cancer detection and prevention},
  year={1999},
  volume={23 4},
  pages={325-32}
}
We have used a modified differential display PCR protocol for isolating 3' restriction fragments of cDNAs specifically expressed or overexpressed in metastatic prostate carcinoma cell line DU145. Several cDNA fragments were identified that matched to milk fat globule protein, UFO/Axl, a receptor tyrosine kinase, human homologue of a Xenopus maternal transcript, laminin and laminin receptor, human carcinoma-associated antigen, and some expressed sequence tags. The transcript for milk fat globule… CONTINUE READING
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