A receptor-mediated pathway for cholesterol homeostasis.

@article{Brown1986ARP,
  title={A receptor-mediated pathway for cholesterol homeostasis.},
  author={M. Scott Brown and Joseph L. Goldstein},
  journal={Science},
  year={1986},
  volume={232 4746},
  pages={
          34-47
        }
}
In 1901 a physician, Archibald Garrod, observed a patient with black urine. He used this simple observation to demonstrate that a single mutant gene can produce a discrete block in a biochemical pathway, which he called an “inborn error of metabolism”. Garrod’s brilliant insight anticipated by 40 years the one gene-one enzyme concept of Beadle and Tatum. In similar fashion the chemist Linus Pauling and the biochemist Vernon Ingram, through study of patients with sickle cell anemia, showed that… 

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Publisher Summary This chapter examines cholesterol metabolism in terms of the molecular events that are responsible for constructing cyclopentanoperhydrophenanthrene derivatives from small molecular
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