A reassessment of biochemical marker distributions in trisomy 21-affected and unaffected twin pregnancies in the first trimester.

@article{Madsen2011ARO,
  title={A reassessment of biochemical marker distributions in trisomy 21-affected and unaffected twin pregnancies in the first trimester.},
  author={Helen N Madsen and Susan D. Stewart Ball and David Wright and Niels T\orring and Olav Bj\orn Petersen and Kypros H. Nicolaides and Kevin Sim{\~o}es Spencer},
  journal={Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology},
  year={2011},
  volume={37 1},
  pages={38-47}
}
OBJECTIVE To estimate the difference between levels of the two biochemical markers pregnancy-associated plasma protein-A (PAPP-A) and maternal serum free β-human chorionic gonadotropin (free β-hCG) in twin pregnancies relative to singleton pregnancies and establish an improved screening procedure for chromosomal abnormalities such as trisomy 21 in twin pregnancies. METHODS 4843 unaffected and 47 trisomy 21-affected twin pregnancies were included in the study. Chorionicity-specific medians… CONTINUE READING

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