A reappraisal of xanthine dehydrogenase and oxidase in hypoxic reperfusion injury: the role of NADH as an electron donor.

@article{Zhang1998ARO,
  title={A reappraisal of xanthine dehydrogenase and oxidase in hypoxic reperfusion injury: the role of NADH as an electron donor.},
  author={Zun Wu Zhang and David R. Blake and Cliff R Stevens and Janos M Kanczler and Paul G. Winyard and Martyn C. R. Symons and Mustapha Benboubetra and Roger Harrison},
  journal={Free radical research},
  year={1998},
  volume={28 2},
  pages={151-64}
}
Xanthine oxidase (XO) is conventionally known as a generator of reactive oxygen species (ROS) which contribute to hypoxic-reperfusion injury in tissues. However, this role for human XO is disputed due to its distinctive lack of activity towards xanthine, and the failure of allopurinol to suppress reperfusion injury. In this paper, we have employed native gel electrophoresis together with activity staining to investigate the role human xanthine dehydrogenase (XD) and XO in hypoxic reperfusion… CONTINUE READING

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