A reappraisal of the relative sensitivity of nematode pharyngeal and somatic musculature to macrocyclic lactone drugs.

@article{Kotze2012ARO,
  title={A reappraisal of the relative sensitivity of nematode pharyngeal and somatic musculature to macrocyclic lactone drugs.},
  author={Andrew C. Kotze and Barney M. Hines and Angela P. Ruffell},
  journal={International journal for parasitology. Drugs and drug resistance},
  year={2012},
  volume={2},
  pages={29-35}
}
Macrocyclic lactone (ML) drugs inhibit pharyngeal pumping, motility and egg laying in parasitic nematodes. Previous work has indicated that in vitro effects on worm feeding occurred at lower ivermectin concentrations than effects on worm motility, suggesting that the pharynx musculature was a more important target site for the ML drugs than somatic musculature. We have reassessed this issue of relative sensitivity by examining the response of drug-susceptible and -resistant adult Haemonchus… CONTINUE READING

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