A reappraisal of the mechanisms underlying the cardiac complications of sickle cell anemia

@article{Rai2017ARO,
  title={A reappraisal of the mechanisms underlying the cardiac complications of sickle cell anemia},
  author={Parul Rai and Omar Niss and Punam Malik},
  journal={Pediatric Blood \& Cancer},
  year={2017},
  volume={64}
}
Anemia, hemolysis‐driven vasculopathy, and intrinsic myocardial injury have been proposed as predisposing factors to cardiac disease in sickle cell anemia (SCA). The individual impact of these mechanisms on the cardiac features of SCA and the way they influence complications such as sudden death and dysrhythmias have been unclear. Recent findings of an acquired restrictive SCA‐related cardiomyopathy, driven by myocardial fibrosis, may explain some of these cardiac features. Given the complexity… Expand
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