A reappraisal of humoral immunity based on mechanisms of antibody-mediated protection against intracellular pathogens.

@article{Casadevall2006ARO,
  title={A reappraisal of humoral immunity based on mechanisms of antibody-mediated protection against intracellular pathogens.},
  author={Arturo Casadevall and Liise-anne Pirofski},
  journal={Advances in immunology},
  year={2006},
  volume={91},
  pages={1-44}
}
Sometime in the mid to late twentieth century the study of antibody-mediated immunity (AMI) entered the doldrums, as many immunologists believed that the function of AMI was well understood, and was no longer deserving of intensive investigation. However, beginning in the 1990s studies using monoclonal antibodies (mAbs) revealed new functions for antibodies, including direct antimicrobial effects and their ability to modify host inflammatory and cellular responses. Furthermore, the… CONTINUE READING